Exjobbsförslag från företag

Detta är ett uppsatsförslag hämtat från Nationella Exjobb-poolen. Klicka här för att komma tillbaka till samtliga exjobbsförslag.

Förslaget inkom 2007-03-19

Light chain amyloidosis- a cruel disease with an unknown pathogenic mechanism

OBS! ANSÖKNINGSTIDEN FÖR DETTA EXJOBB HAR LÖPT UT.
In amyloidosis, a normally soluble protein is transformed to an abnormal fibrillar aggregate. The clinical symptoms of amyloidosis vary and the severity of the disease depends on which the amyloidogenic protein is and where it is deposited in the body. Today, 25 different proteins have been demonstrated to be amyloidogenic in vivo and associated with severe syndromes like Alzheimer’s disease, type-2 diabetes and light chain amyloidosis.
Light chain (AL) amyloidosis is caused by deposition of amyloid fibrils derived from monoclonal immunoglobulin light chains produced by a plasma cell clone in the bone marrow. These large systemic deposits in the tissue, sometimes resulting in a liver of 15 kg (10 times the normal weight!), indeed have severe consequences for the patients. The most common outcomes are renal failure, cardiac and liver diseases and neuropathy. Most patients diagnosed with AL amyloidosis only survive 1-2 years. We would greatly appreciate help in trying to understand how this amyloid is formed, what the deposits are built up of and determine which factors that influence the aggregation propensity of the light chains.
Methods that will be used are for example, size exclusion chromatography, RP-HPLC, MALDI-TOF-MS, Western blot, ELISA, and immunohistochemistry.



  GÅ TILL XJOBB.NU FÖR FULLSTÄNDIG INFO OM DETTA EXJOBB




Informationen om uppsatsförslag är hämtad från Nationella Exjobb-poolen.