Exjobbsförslag från företag

Detta är ett uppsatsförslag hämtat från Nationella Exjobb-poolen. Klicka här för att komma tillbaka till samtliga exjobbsförslag.

Förslaget inkom 2007-12-13

Kopia av Membrane assembly of human G-protein coupled receptors

OBS! ANSÖKNINGSTIDEN FÖR DETTA EXJOBB HAR LÖPT UT.
Most secretory proteins as well as proteins destined for the plasma membrane and organelles of the secretory pathway, contains an amino-terminal signal sequence, which triggers translocation into the endoplasmic reticulum (ER). This translocation can occur cotranslationally where the signal sequence interacts with a signal recognition particle (SRP) which targets the ribosome-bound nascent chain to translocation sites, so called translocons, in the ER membrane. In other cases proteins are translocated posttranslationally. Posttranslational translocation is found in all eukaryotic cells, but the mechanism in mammalian cells is not well understood. Proteins belonging to the medically very important G-protein coupled receptor (GPCR) superfamily, including the opioid, cannabinoid and adrenergic receptors, contain seven transmembrane spanning domains having their N-terminal externally and C-terminal internally. For some members of this family the N-tail is translocated posttranslationally. How these receptors are able to translocate their N-tails using this pathway, why they use this pathway and determining what cellular factors are involved are questions being addressed in this project.



  GÅ TILL XJOBB.NU FÖR FULLSTÄNDIG INFO OM DETTA EXJOBB




Informationen om uppsatsförslag är hämtad från Nationella Exjobb-poolen.