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Förslaget inkom 2003-09-17

Ribonucleotide reductase database

OBS! ANSÖKNINGSTIDEN FÖR DETTA EXJOBB HAR LÖPT UT.
Background:
Ribonucleotide reductases (RNRs) catalylze the reduction of ribonucleotides to deoxyribonucleotides, providing cells with buildning blocks for DNA synthesis and repair.

Currently, three different classes (I-III) of RNRs are known. All three classes are related via divergent evolution, and ribonucleotide reduction is considered to have emerged concurrent with the origin of DNA.

Project:
You will establish a database of ribonucleotide reductase genes, structural and biochemical data, providing a valuable tool for ongoing functional and evolutionary studies. The database will link data stored in Genbank (http:// www.ncbi.nlm.nih.gov/Entrez/) and the Protein Databank (http://www. rcsb.org/pdb/) with biochemical data in the published literature. In addition, there will be scope for some bioinformatic work or complementary lab work.

We are seeking a student who has a background in molecular biology, and is also interested in developing skills in bioinformatics. Prior knowledge of database creation is welcome, but not required.

Information about the department and recent publications can be found at http://www.molbio.su.se.

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