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Förslaget inkom 2003-01-20

Quantitative Trait Analysis in the Genetics of Complex Human Diseases

OBS! ANSÖKNINGSTIDEN FÖR DETTA EXJOBB HAR LÖPT UT.
A new era of genetics research has sprung forth with the completion of the draft sequence of the human genome. This has provided us with a wealth of information which stands to vastly improve our understanding of human disease.
In our group we are presently focussing on Alzheimer´s disease and Cardiovascular disease, which both have complex etiologies in which the majority of afflicted individuals have no defined genetic cause. To better understand how genetics contributes to these disorders, we employ a broad range of methods, with a primary focus on genotyping single nucleotide polymorphisms (SNPs) in patient DNA materials. To identify candidate genes which may underlie these diseases, we concentrate on quantitative traits related to the disorders, such as measures of cognitive function and cerebral spinal fluid levels of the protein Tau in Alzheimer´s disease. By narrowing the definition of ´phenotype´ one dramatically improves their chances of finding significant genetic associations with disease. The proposed project entails developing genotyping assays for SNPs in candidate genes and performing genotyping experiments in patient materials. Apart from excellent hands-on experience in a modern genetics laboratory setting, students will also benefit from extensive work utilising the world-wide genetics databases and other in-silico genetics tools.


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