Exjobbsförslag från företag

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Förslaget inkom 2010-10-18

Thesis work - Analysis of transgenic mouse models of inflammation

OBS! ANSÖKNINGSTIDEN FÖR DETTA EXJOBB HAR LÖPT UT.
Your role
Generation of plasmid DNA constructs using standard molecular biology techniques. Characterisation of transgenic mouse models.

Your experience
You are student with some experience/interest in molecular biology and physiological characterization of transgenic mouse models.

Work at AstraZeneca
Molecular biology, bioluminescence assays, immunoassays, in vivo analysis of mouse models.

This project aims to validate inflammation mouse models using in vivo assays of cancer and inflammation. In addition new models may be considered and suitable plasmid DNA constructs will be generated using standard molecular biology techniques and tested in vitro through bioluminescence and immunoassay in cell culture.

Macrophages are immune cells involved in a range of inflammatory responses associated with specific diseases including obesity. We are in the process of generating mouse models designed to allow functional imaging of inflammation in vivo. Models where macrophages are engineered to emit light or express specific transporters under the regulation of a macrophage specific promoter permit the use of bioluminescence and Magnetic Resonance Imaging techniques to be employed to look at inflammatory responses in vivo.

For more information
John Wiseman, +46 31 706 54 17.

Welcome with your application no later than October 31st.


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Informationen om uppsatsförslag är hämtad från Nationella Exjobb-poolen.