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Förslaget inkom 2012-01-17

Multivariate comparison of voxel-based versus morphometric analysis

OBS! ANSÖKNINGSTIDEN FÖR DETTA EXJOBB HAR LÖPT UT.
The need for a better understanding of brain atrophy in normal and pathological conditions has motivated the development of models derived from anatomical brain images such as Magnetic Resonance Imaging (MRI). Voxel-based morphometry (VBM) is a well-established technique for medical image processing and analysis. It allows the comparison of focal differences in brain anatomy by applying statistical parametric mapping (SPM) based on general linear modeling (GLM) to obtain probability maps of significant difference between groups of patients. FreeSurfer is an automated pipeline that produces regional cortical thickness and volumetric measures. This segmentation approach has been successfully applied for multivariate classification of Alzheimer's disease subjects and healthy controls.

The objective of the project is to compare anatomical features obtained from FreeSurfer versus selected features derived from VBM applying multivariate statistics and demonstrate their advantages and disadvantages.

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