Exjobbsförslag från företag

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Förslaget inkom 2003-01-20

Molekylära mekanismer vid blodkärlsnybildning i tumörtillväxt och vid metastasering

Angiogenesis, the outgrowth of new capillaries from pre-existing vessels, is essential for wound healing, female reproduction, embryonic development, organ formation, and for tissue regeneration and remodelling.

    Abnormal growth of blood vessels can lead to the development and progression of diseases such as tumor growth and metastasis, diabetic retinopathy and cardiovascular diseases.

   The process of neovascularization depends upon the tightly regulated growth of endothelial cells which can be switched on and off within a short time. Like any other tissues in the body, the growth of tumors requires blood supply. Thus, suppression of blood vessel growth in tumors could in principle delay tumor growth. Tumors often switch on their angiogenic phenotypes by overproduction of one or more angiogenic factors, which stimulates blood vessel growth, and by simultaneous down-regulation of angiogenesis inhibitors.

   In our lab, we investigate signal transduction pathways that lead to endothelial cell proliferation and migration, key events in the process of angiogenesis.  We also study the process of angiogenesis using several different animal models, such as the chick chorioallantoic membrane model and the mouse corneal angiogenesis assay. We are working on the characterization of novel angiogenic factors, as well as trying to identify new angiogenesis inhibitors that can block blood vessel growth.

  We are interested in studying the molecular mechanisms of the angiogenic switch in tumors and other diseases by characterizing the biological functions of a number of angiogenic factors and their signalling events.

   Our research group is interested in studying the switch of the angiogenic phenotype in tumors by identification, isolation and characterization of novel angiogenesis regulators. Our ultimate goal is to develop strategies that could stop tumor growth and metastasis.

We would like to welcome exam work students to participate in these projects during 10-20 weeks. Preferably, you have some general biochemical/physiological/biomedical training and a strong interest in tumor- and cellbiologi.


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